Chemicals programme in OECD.
نویسندگان
چکیده
منابع مشابه
Oecd Guideline for the Testing of Chemicals
1. The term skin sensitiser refers to a substance that will lead to an allergic response following skin contact as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS) (United Nations UN, 2013). This Test Guideline provides an in vitro procedure called the Interleukin-8 Reporter Gene Assay (IL-8 Luc assay), which is useful for distinguis...
متن کاملOecd Guidelines for the Testing of Chemicals
1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of...
متن کاملOecd Guideline for the Testing of Chemicals
1. OECD Guidelines are periodically reviewed in the light of scientific progress, changing regulatory needs, and animal welfare considerations. The original acute inhalation Test Guideline 403 (TG 403) was adopted in 1981 (1). This revised TG 403 has been designed to be more flexible, to reduce animal usage, and to fulfil regulatory needs. The revised TG 403 features two study types: a Traditio...
متن کاملOecd Guideline for the Testing of Chemicals
1. The OECD Test Guideline Programme periodically reviews progress in test method development and refinement, both in terms of scientific advances and animal welfare, to determine whether existing Test Guidelines should be updated and whether new Guidelines should be developed. Toward that end, a new assay for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLN...
متن کاملOecd Guideline for the Testing of Chemicals
1. OECD guidelines are available for a wide range of in vitro mutation assays that are able to detect chromosomal and/or gene mutations. However, while in vivo assays in somatic tissues are desirable components of a thorough genetic toxicity testing programme, aside from the little-used (Wahnschaffe et al., 2005) rodent Spot Test (TG 484), OECD guidelines are available only for assays capable o...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1988
ISSN: 0013-273X
DOI: 10.1248/jhs1956.34.381